What Makes a Good Nucleophile for Sn2
See chapter 6 of your textbook to learn what makes a good nucleophile or a. Strong nucleophiles generally bear a negative charge such as RO- -CN and -SR. What Makes A Good Nucleophile 2 Teaching Chemistry Medical School Stuff Organic Chem NH2- is a better nucleophile than NH3. . For an SN2 reaction - which makes the best nucleophile. Click to see full answer. The SN2 reaction is favored by polar aprotic solvents these are solvents such as acetone DMSO acetonitrile or DMF that are polar enough to dissolve the substrate and nucleophile but do not participate in hydrogen bonding with the nucleophile. - Small negatively charged nucleophile -Bulky nucleophile -Small neutraluncharted nucleophile -Neutraluncharged nucleophile The observations in elimination reactions can generally predict the products by using Zaitsevs rule which is. The weak conjugate bases are poor nucleophiles. So SN2 reactions are usually run in medium polari...